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CRICH GROUP

Publications

2024

Thomas D. Beckler and David Crich

Synthesis of N-Alkyl-1,3-dihydro-2,1-benzisoxazoles

Org. Lett. 2024, xxxx, xxx, xxx-xxx,

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Daniil Ahiadorme and David Crich

Entropy-Enthalpy Compensation in the Methyl 5-Thio-α-D-galactopyranoside–Jacalin Interaction

Carb. Res. 2024, 109305

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David Crich

Chemical synthesis-based structure correction of a claimed protein-free antifreeze oligosaccharide

National Science Review, 2024

Jarvis Hill, R. Houston Givhan, Bin Yi, Robert M. Jones, Eugene F. Douglass, Yaguang Xi, Henry F. Schaefer III, and David Crich

Computationally Driven Discovery of a BCR-ABL1 Kinase Inhibitor with Activity in Multidrug-Resistant Chronic Myeloid Leukemia

J. Med. Chem. 2024, 67, 19, 17820–17832

Niteshlal Kasdekar, Michael R. Spieker, and David Crich

Practical Synthesis from Streptomycin and Regioselective Partial Deprotections of (−)-(1R,2S,3R,4R,5S,6S)-1,3-Di(deamino)-1,3-diazido-2,5,6-tri-O-benzylstreptamine

J. Org. Chem. 2024, 89, 6, 4225–4231

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Sonja Gross, Sebastian Herren, Marina Gysin, Anna Rominski, Anna Roditscheff, Martin Risch, Frank Imkamp, David Crich and Sven N. Hobbie

In vitro susceptibility of Neisseria gonorrhoeae to netilmicin and etimicin in comparison to gentamicin and other aminoglycosides

Microbiol Infect Dis, 2024, 43, 821–828

Omar Awad Alsaidan, Emmanuel Onobun, Chenming Ye, Lei Lou, Zanna Beharry, Zhong-Ru Xie, Iryna Lebedyeva, David Crich, Houjian Cai

Inhibition of N‐myristoyltransferase activity promotes
androgen receptor degradation in prostate cance

The Prostate. 2024, 84, 254-268

Ruslans Muhamadejevs, Klara Haldimann, Marina Gysin, David Crich, Kristaps Jaudzems, and Sven N. Hobbie

Experimental Determination of the pKa Values of Clinically Relevant Aminoglycoside Antibiotics: Toward Establishing pKa─Activity Relationships

ACS Omega 2024, 9, 5, 5876–5887

2023

Atypical N-Alkyl to N-Noralkoxy Switch in a Dual cSRC/BCR-ABL1 Kinase Inhibitor Improves Drug Efflux and hERG Affinity

Jarvis Hill, Robert M. Jones, and David Crich

ACS Med. Chem. Lett. 2023, 14, 12, 1869–1875

Discovery of a Hydroxylamine-Based Brain-Penetrant EGFR Inhibitor for Metastatic Non-Small-Cell Lung Cancer

Jarvis Hill, Robert M. Jones, and David Crich

J. Med. Chem. 2023, 66, 22, 15477–15492

Synthesis and Evaluation of Novel 5-O-(4-C-Aminoalkyl-β-D-ribofuranosyl) Apramycin Derivatives for the Inhibition of Gram-Negative Pathogens Carrying the Aminoglycoside Phosphotransferase(3′)-Ia Resistance Determinant

Dmitrijs Lubriks, Klara Haldimann, Fatmanur Kiliç, Maximilian Hartmann, Erik C. Böttger, Sven N. Hobbie, Edgars Suna, and David Crich

Helv. Chim. Acta 2023, 106, e202300138

Stereodirecting Effect of Esters at the 4-Position of Galacto- and Glucopyranosyl Donors: Effect of 4-C-Methylation on Side-Chain Conformation and Donor Reactivity, and Influence of Concentration and Stoichiometry on Distal Group Participation

Chennaiah Ande and David Crich

J. Org. Chem. 2023, 88, 19, 13883–13893

Synthesis of Gentamicins C1, C2, and C2a and Antiribosomal and Antibacterial Activity of Gentamicins B1, C1, C1a, C2, C2a, C2b, and X2

Santanu Jana, Parasuraman Rajasekaran, Klara Haldimann, Andrea Vasella, Erik C. Böttger, Sven N. Hobbie, and David Crich

ACS Infect. Dis. 2023, 9, 8, 1622–1633

Synthesis of 4-O-(4-amino-4-deoxy-b-D-xylopyranosyl)paromomycin and 4-S-(b-D-xylopyranosyl)-4-deoxy-40 -thio-paromomycin and evaluation of their antiribosomal and antibacterial activity

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Rukshana Mohamad-Ramshan, Chennaiah Ande, Takahiko Matsushita, Klara Haldimann, Andrea Vasella, Sven N. Hobbie, and David Crich

Tetrahedron 2023, 135, 133330

Recent Advances in the Synthesis of Di- and Trisubstituted Hydroxylamines

Jarvis Hill, Thomas D. Beckler, and David Crich

Molecules 2023, 28(6), 2816

Can Side-Chain Conformation and Glycosylation Selectivity of Hexopyranosyl Donors Be Controlled with a Dummy Ligand?

Kapil Upadhyaya, Nicolas Osorio-Morales, and David Crich

J. Org. Chem. 2023, 88, 6, 3678–3696

Synthesis and evaluation of 1,5-dithialaminaribiose and -triose tetravalent constructs

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Daniil Ahiadorme, Chennaiah Ande, Rafael Fernandez-Botran, and David Crich

Carb. Res. 2023, 525,108781

Influence of Side Chain Conformation on the Activity of Glycosidase Inhibitors

Po-Sen Tseng, Chennaiah Ande, Kelley W. Moremen, and David Crich

Angew. Chem. 2023, 135, e202217809

Importance of Co-operative Hydrogen Bonding in the Apramycin-Ribosomal Decoding A-Site Interaction

Michael G. Pirrone, Chennaiah Ande, Klara Haldimann, Sven N. Hobbie, Andrea Vasella, Erik C. Böttger, and David Crich

ChemMedChem 2023, 18, e202200486

Past

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